UltraMIST® - Validated by Clinical Studies

Tens of Thousands of Patients Treated

3 Studies - 54,888 Patients View Data

Evidence Level lb


Randomized Controlled Trials4-11 8 Studies - 509 Patients View Data

Evidence Level lb

RCT (Randomized Controlled Trial)

Prospective12-14: 3 Studies - 32 Patients View Data

Retrospective15-18 4 Studies - 369 Patients View Data

Evidence Level IIa

Control Without Randomization

Evidence Level IIb


4 Studies - 180 Patients View Data

Evidence Level III

Descriptive Studies

Footnotes for Page

1. Low-frequency ultrasound (20-40 kHz) as an adjunctive therapy for chronic wound healing: a systematic review of the literature and meta-analysis of eight randomized controlled trials
2. Seeking effective interventions to treat complex wounds: an overview of systematic reviews
3. Noncontact Low-Frequency Ultrasound Therapy in the Treatment of Chronic Wounds: A Meta-Analysis Driver VR, Yao M, Miller CJ
4. A Prospective, Randomized, Controlled Trial Comparing the Effects of Noncontact, Low-frequency Ultrasound to Standard Care in Healing Venous Leg Ulcers
5. Prospective Randomized Controlled Trial Comparing the Effects of Noncontact Low-Frequency Ultrasound with Standard Care in Healing Split-Thickness Donor Sites.
6. Non-contact low-frequency ultrasound therapy compared with UK standard of care for venous leg ulcers: a single-centre, assessor-blinded, randomised controlled trial.
7. Comparison of High-Frequency and MIST Ultrasound Therapy for the Healing of Venous Leg Ulcers
8. High-frequency and noncontact low-frequency ultrasound therapy for venous leg ulcer treatment: a randomized, controlled study
9. A pilot study evaluating non-contact low-frequency ultrasound and underlying molecular mechanism on diabetic foot ulcers
10. Treatment of ischemic wounds with noncontact, low-frequency ultrasound: the Mayo clinic experience, 2004-2006
11. Ultrasound therapy for recalcitrant diabetic foot ulcers: results of a randomized, double-blind, controlled, multicenter study
12. Healing Rate of Chronic and Subacute Lower Extremity Ulcers Treated With Contact Ultrasound Followed by Noncontact Ultrasound Therapy: The VIP Ultrasound Protocol
13. The Impact of Noncontact, Nonthermal, Low-Frequency Ultrasound on Bacterial Counts in Experimental and Chronic Wounds
14. A prospective pilot study of ultrasound therapy effectiveness in refractory venous leg ulcers
15. Expedited wound healing with noncontact, low-frequency ultrasound therapy in chronic wounds: a retrospective analysis
16. Effects of non contact low‐frequency ultrasound on healing of suspected deep tissue injury: a retrospective analysis
17. Use of noncontact low-frequency ultrasound in the treatment of chronic foot and leg ulcerations: a 51-patient analysis
18. Evaluation of clinical effectiveness of MIST ultrasound therapy for the healing of chronic wounds
19. Adjuvant use of acoustic pressure wound therapy for treatment of chronic wounds: a retrospective analysis.
20. A retrospective analysis of acoustic pressure wound therapy: effects on the healing progression of chronic wounds
21. Noncontact ultrasound therapy for adjunctive treatment of nonhealing wounds: retrospective analysis
22. The effect of noncontact, low-intensity, low-frequency therapeutic ultrasound on lower-extremity chronic wound pain: a retrospective chart review.

In a Meta-Analysis of Preclinical and Clinical Evidence* for Advanced Wound Closure, SANUWAVE Ultrasound Mist System Therapy Achieves:

Venous leg uclers


Wound area reduction at 4 weeks

Vs. 45% std of care, p = 0.024

Venous leg uclers


Reduction in VAS pain measurement

Vs. 20% std of care, p = 0.014

Split Thickness Donor Sites

18 Days

Time to full epithelization

Vs. 27 days std of care, p = 0.035

Diabetic Foot Ulcers


Reduction in wound area at 4 weeks

Vs. 39% std of care, p = 0.059

Diabetic Foot Ulcers


Wound Closure

Vs. 14% std of care, p = 0.0411

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